Initially, Dr. Brennan dislikes Margaret, which Dr.Sweets would tell her is because Margaret's off-putting personality is too similar to Dr. Brennan's own social difficulties. Booth notes a striking physical similarity between Dr. Brennan and Margaret, suggesting that they could easily pass for sisters (which the actresses are in real life). During Christmas dinner, Dra. Brennan finally expresses her irritation with Margaret's habit of quoting Benjamin Franklin, explaining that it is not really communication and that she would prefer to hear what Margaret has to say herself (without using Franklin as a proxy). Margaret replies, "That's the nicest thing anyone's ever said to me."